Therefore, to expand our knowledge of the role of FGFRs in Sq-NSCLC as well as their use as potential biomarkers for FGFRi treatment, a comprehensive evaluation of FGFR aberrations and their clinical importance in Sq-NSCLC was conducted using real-time PCR (RT-PCR) and next-generation sequencing (NGS) to assess gene expression, fusions, and variants, as well as FGFR1–3 protein expression and FGFR1 amplification. This evidence concerns the gene FGFR1 and non-small cell lung carcinoma.