To determine the role of AT-derived macrophages in cardiac remodeling after MI, a hematopoietic repopulation assay was performed, using AT-HSC or BM-HSC isolated from mice expressing the diphtheria toxin receptor (DTR) under control of the full CD11c promoter [7], mixed with competitor BM cells from mT/mG mice, and transplanted into lethally irradiated mT/mG recipient mice. The gene discussed is HBEGF; the disease is myocardial infarction.