For example, hispolon derived from Phellinus linteus inhibited the invasion and motility of a highly metastatic liver cancer cell line (SK-Hep1) by downregulating MMP2, MMP9, and uPa, and inhibiting the activation of the ERK1/2, PI3K/AKT, and FAK pathways [38]. Here, AKT1 is linked to liver cancer.