Although it is not specific for LEAD, a case-control GWAS of 177 patients with thromboangiitis obliterans (TAO) identified three SNPs (rs376511 in the IL17RC gene, rs7632505 in the SEMA5B gene, and rs10178082 in the RPA3 gene) that were significantly associated with TAO in the Uighur population [33]. This evidence concerns the gene SEMA5B and thromboangiitis obliterans.