APOE and Stroke: Starting from the known fact that certain APOE allelic variants are associated with CAD and stroke, they showed that, of the six known APOE genotypes (APOE2/2, APOE2/3, APOE2/4, APOE3/3, APOE3/4, APOE4/4), the homozygous APOE2/2 (ε2/ε2) genotype is associated with an increased risk of LEAD in patients at a high risk of CVD.