GAPDH and cancer: Glucose transporters and enzymes with a pivotal role in glycolysis, such as hexokinase II (HKII), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), lactate dehydrogenase (LDH), and the isoform M2 of pyruvate kinase (PKM2) are usually upregulated in cancer cells and have been proposed as possible therapeutic targets.