A growing amount of data from in vitro and in vivo studies has shown that flavonoids act as chemopreventive agents and increase the efficacy of chemotherapy and radiotherapy in various cancers by regulating the activity of Akt, NF-κB, cyclooxygenase (COX)-2, c-Myc, apoptotic, and other pathways. Here, NFKB1 is linked to cancer.