The antitumor activity of curcumin, epigallocatechin gallate (EGCG), or indole-3-carbinol (I3C) in MDA-MB-231 breast cancer cells was confirmed through the inhibition of clonogenic growth by 55% to 60%, an increase in basal caspase-3/7 activity by 1.5 to 2 times, and a prolonged doubling time, while genistein did not show an anticancer effect on the same cells [121]. Here, CASP3 is linked to breast cancer.