As mentioned, HIF-1 induces the expression of various genes, most of them being related to the low (or null) oxygen consumption/metabolism, and the stimulation of neoangiogenesis through increased HIF-1/VEGF secretion, both in cancer cells and in peritumoral fibroblasts, macrophages, myofibroblasts, and endothelial cells. The gene discussed is HIF1A; the disease is cancer.