Recently the different temozolomide and valproic acid effects on tumorigenesis mechanisms have been reported, such as their effect on tumor growth, the histological expression of PCNA and EZH2 in tumor cells, Na-K-2Cl, K-Cl, and SLC5A8 co-transporter gene expression in pediatric glioblastoma PBT24 and SF8628 cell tumors on chick embryo chorioallantoic membranes (CAM) and on corresponding cells in vitro, highlighting the importance of studies on efficacy in the context of individualized anticancer therapy [37,38]. This evidence concerns the gene PCNA and neoplasm.