This study investigated tumors formed from a high-grade glioblastoma SF8628 (3-year-old girl’s) and a high-grade glioblastoma PBT24 (13-year-old boy’s) cell line cells using a CAM model; we tested the tumor response to treatment with magnesium or sodium dichloroacetate salt preparations (MgDCA and NaDCA) on PCNA, EZH2, p53, and survivin expression in xenograft tumors on CAM; and we explored the effects of MgDCA and NaDCA on Na-K-2Cl (SLC12A2), K-Cl (SLC12A5), SLC5A8 co-transporters, and E-cadherin (CDH1) and N-cadherin (CDH2) gene expression in studied phGBM cells. Here, SLC5A8 is linked to glioblastoma.