The authors of this study observed higher activities of glucose-6-phosphate-dehydrogenase (G6PD), transketolase (TKT), and transaldolase (TALDO) in the failing heart compared to healthy donors; however, significantly higher levels of the G6PD, TKT, and TALDO, along with significant reductions of sedoheptulose-7-phosphate and fructose-6-phosphate were observed in HF patients who responded positively after mechanical unloading (LVEF > 40% and a left ventricular end-diastolic diameter of <6 cm) compared to those who did not respond [52]. The gene discussed is G6PD; the disease is hydrops fetalis.