LDHA and gastric cancer: Shao et al. found that down-regulation of circ-DONSON can enhance the radiosensitivity of gastric cancer cells, which accelerates GC progression through the miR-149-5p/LDHA axis, inhibits cell proliferation, migration, invasion, and angiogenesis to a certain extent, and enhances cell apoptosis, suggesting that it may be a promising biomarker for GC therapy [42].