Further studies showed that circ-0055625 can act as a sponge for miR-338-3p, and knockout of circ-0055625 can block cell proliferation, migration, and invasion by regulating the miR-338-3p/MSI1 axis, and improve colon cancer cell proliferation, apoptosis, and radiosensitivity. Here, MSI1 is linked to malignant colon neoplasm.