MDM2 and colorectal carcinoma: Among them, CDR1as has been discussed before, and functions as a CRC promoter by binding to miR-7 in the IIS pathway, while in the p53 signaling pathway, it can directly bind to the DNA-binding domain (DBD) region of p53 to restrict its interaction with MDM2 and prevent p53 degradation to inhibit GBM [145].