PITX1 and non-small cell lung carcinoma: Similar to circ-PLCD1, circ-PITX1 facilitates NSCLC proliferation and metastasis by sponging miR-30E-5p, which then targets the 3′ untranslated region (UTR) of integrin subunit alpha 6 (ITGA6) and ultimately activates the PI3K/AKT pathway [108].