Combined treatment of EMP + Alda-1 ameliorated the hallmarks of diabetes-associated HFpEF, such as cardiac diastolic function and exercise capacity as well as decreased cardiomyocyte hypertrophy and myocardial fibrosis, more than the individual treatment with EMP in ALDH2*2 mice. The gene discussed is ALDH2; the disease is Myocardial fibrosis.