ALDH2 and type 2 diabetes mellitus: Our ALDH2*2 E487K knock-in mutant mice mimic East Asians with the ALDH2*2 E487K mutation [22,23] and we demonstrated that this ALDH2*2 E487K knock-in mutant mice with HFD-fed type-2 diabetes recapitulated major characteristics of HFpEF [6].