We found a significant increase in colocalization of LKB1 and 4HNE in the hearts of vehicle-treated ALDH2*2 mice with diabetes-associated HFpEF compared to the non-diabetic controls, implicating increased 4HNE adduction on LKB1 (Figure 7A,B,F,G,K,L,P,Q). The gene discussed is ALDH2; the disease is diabetes mellitus.