More than 850 PCSK9 mutations have been reported, and studies have demonstrated that the more common loss-of-function (LOF) mutations are associated with hypocholesterolemia and protection against coronary heart disease, but that the disease-related dominant gain-of-function (GOF) mutations cause familial hypercholesterolemia and coronary heart disease [23,24]. Here, PCSK9 is linked to coronary artery disorder.