MACO1 and diabetes mellitus: We also assessed the associations of individual LDL-C-level-determining SNVs with DM after further adjustment for LDL-C levels; the results indicated that six SNVs–namely, APOE rs7412, PMFBP1 rs3852789, TMEM8A rs375498857, SLC10A1 rs2296651, TRIM5 rs16934050, and MACO1 rs61775184—were significantly associated with DM (all p < 0.01).