Mutations in the Sam domains of Bicaudal C homolog 1 (Bicc1) and one of its binding partners (i.e., ANKyrin repeat and Sterile α motif domain-containing six (ANKS6)) lead to kidneys diseases, whereas mutations in the Sam domain belonging to the tyrosine kinase receptor EphA2 (Ephrin receptor A2) are related to cataracts. The gene discussed is BICC1; the disease is kidney disorder.