However, LCA by targeting EphA2 LBD, is able to hamper receptor autophosphorylation induced by stimulation by ephrin A1-Fc in human prostate cancer cells and colon adenocarcinoma cell lines (PC3 and HT29) and avoids rounding and retraction of PC3 cells caused by EphA2 activation [97]. This evidence concerns the gene EFNA1 and Familial prostate cancer.