Intriguingly, encapsulation into hollow mesoporous silica nanoparticles (HMSNs) and further coating within a lipid bilayer containing entrapped monophosphoryl lipid A adjuvant enhanced the stability and codelivery efficacy of HGP10025–33 and TRP2180–188 peptides, thus allowing for the inhibition of tumor growth and lung metastasis in murine melanoma models with a decent safety profile; polymeric NPs based on chitosan instead allow lactoferrin to activate apoptotic pathways in colon cancer and cancer stem cells [43,44,46]. The gene discussed is LTF; the disease is cancer.