In agreement, the same authors found that irisin levels in the cerebrospinal fluid of AD patients were positively correlated with increased BDNF and cognitive performance, confirming the ability of this myokine to modulate BDNF expression at the hippocampal level and providing further evidence for its involvement in neuroinflammatory responses and neurodegeneration [31]. The gene discussed is BDNF; the disease is Alzheimer disease.