AKT1 and cancer: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed enrichment in cancer stemness-related signaling pathways (Hedgehog, calcium, Wnt, PPAR, TGF/SMAD, and PI3K/Akt signaling pathway) [27] in resistant PTC when compared to antineoplastic-sensitive PTC (Figure 2D–F).