To clarify the clinical significance of the Hedgehog pathway in the treatment of TNBC, we used the Oncomine database and Kaplan–Meier analysis and assessed the expression of key factors (SHH, PTCH1, SMO, GLI1, and GLI2) of the Hedgehog pathway in normal breast tissue and breast cancer tissue, along with their relationship to the prognosis of breast cancer patients. This evidence concerns the gene SMO and breast cancer.