Our group previously demonstrated, through in vitro experiments, that cordycepin induced apoptosis and regulated the apoptotic factors in breast cancer cells; affected the expression of motility-, migration, invasion-, and epithelial–mesenchymal transition (EMT)-related proteins; inhibited the expression of the Hedgehog pathway components and GLI transcription activity; and knocking out GLI blocked the effects of cordycepin on apoptosis, EMT, and the Notch pathways, suggesting that the Hedgehog pathway and its related targets play an important role in breast cancer inhibition [11]. The gene discussed is GLI1; the disease is breast cancer.