The remainder of the top 10 downregulated molecules included ankyrin repeat domain 45 (ANKRD45, −4.213), a nuclear protein involved in protein binding; IL6R antisense RNA 1 (IL6R-AS1, −4.159), an anti-sense RNA; PDZ domain containing 4 (PDZD4, −3.807), which has a cytoplasmic location and which is upregulated in synovial sarcomas [26]; senescence associated long noncoding RNA 2 (SALRNA2, −3.573), a noncoding RNA; and finally LIM domain only 3 (LM03, −3.353), a nuclear transcription coregulator. Here, ANKRD45 is linked to synovial sarcoma.