Interestingly, the expression of the small proline-rich protein 1 (SPRR1), which promotes axonal growth, is reportedly increased after stroke [72,108,120,121], and hypomethylation induced by treatment with 5-azacytidine, a DNMT inhibitor, in keratinocytes, leads to rapid upregulation of SPRR1 [122]. The gene discussed is SPRR1B; the disease is stroke disorder.