To understand the changes occurring in the gene transcription complex according to the changes in MBD expression, with the exception of direct regulation of DNA methylation after cerebral infarction, the increase in the MBD2/MBD3 ratio and the expression of MeCP2 and MBD1 were confirmed in the CA1 region of the hippocampus after cerebral infarction [7,24]. The gene discussed is MBD1; the disease is cerebral infarction.