In the mechanisms of recovery after stroke, including neurogenesis, angiogenesis, axonal growth, and synaptic plasticity, via regulation of DNMTs, DNMT1, and DNMT3a, hypermethylation or hypomethylation is induced not only in the global gene promotor but also in the promotor regions of galanin, Ng2, THBS1, SPRR1, and BDNF genes. Here, SPRR1B is linked to Stroke.