BDNF and Stroke: In the hippocampus of depressed mice after stroke, DNA methylation was significantly increased in the specific CpG region of the Bdnf promoter IV, and MeCP2 was bound to the methylated BDNF promoter, resulting in a repressor complex, which prevented the cAMP response element (CRE) from binding to the CRE-binding protein (CREB) and suppressed Bdnf gene transcription [137].