The increased protein level of the protein phosphatase magnesium dependent 1A (PPM1A), one of the inflammatory control gene, is caused by induction of the hypomethylation of the PPM1A promoter, and the increased PPM1A protein has been found to increase the stroke recurrence by involving the regulation of the transforming growth factor-β (TGF-β) pathway [72]. Here, PPM1A is linked to Stroke.