In the asthenospermia mouse model induced by CTX, the body weight, epididymis index, sperm motility (PR + NP), and sperm concentration were significantly lower than those in control groups (p < 0.05); after being treated with CNP, the body weight, epididymis index, sperm motility (PR + NP) and sperm concentration were significantly improved than those in CTX groups (p < 0.05) (Table 2). This evidence concerns the gene CNP and Reduced sperm motility.