DNM2 and centronuclear myopathy: In this regard, it has been reported that impaired GLUT-4 insertion into the plasmalemma of human myoblasts and mice myofibers expressing the dynamin-2 p.R465W mutation causes mild late-onset CNM and aberrant perinuclear accumulation of this glucose transporter in biopsies from CNM patients carrying the p.R465W mutation [21].