The aim of this work was to study the levels and identify the relationships of the following factors in PF of patients with endometriosis: ten energy metabolism markers (C-peptide, ghrelin, GIP, GLP-1, glucagon, insulin, leptin, PAI-1 (total), resistin, and visfatin); the expression of GLP1R receptors and proteases CD10 and CD26 by macrophages, which can damage the mentioned signaling molecules; and the expression of surface pro-inflammatory marker CD86. This evidence concerns the gene RETN and endometriosis.