TMPRSS2 and COVID-19: Moreover, according to the in silico studies employing hesperetin and hesperidin as the potential anti-viral agents against COVID-19, hesperetin was found to bind the two cellular proteins: transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2), which are required for the cellular entry of SARS-CoV-2 [47].