The serum levels of TNFα, TNFβ, TGFα, IL-10, sRAGE, sTNF-RI and sTNF-RII in both groups of severe COVID-19 patients were significantly elevated compared to those found in the healthy controls (surviving patients vs. controls: p = 0.003, p = 0.008, p < 0.0001, p = 0.001, p < 0.0001, p < 0.0001 and p < 0.0001, respectively; non-surviving vs. controls: p < 0.0001, p = 0.002, p < 0.0001, p < 0.0001, p < 0.0001, p < 0.0001 and p < 0.0001, respectively) (Figure 2A,B). Here, TNF is linked to COVID-19.