Taking into account the innate and innate/adaptive cytokines and soluble receptors analyzed in the serum, we found that severe COVID-19 with lower levels of IL-15, IL-6, IL-18, IL-27, IL-10, sIL-1RI, sIL-1RII and sTNF-RII, and higher levels of SCD40L showed significantly better predictive survival curves. Here, CD40LG is linked to COVID-19.