The surviving severe COVID-19 patients showed significantly lower circulating concentrations of TNFα, TGFα, IL-10, sRAGE, sTNF-RI and sTNF-RII compared to the non-survivors (p = 0.001, p = 0.031, p < 0.0001, p < 0.0001, p = 0.001 and p < 0.0001, respectively). This evidence concerns the gene IL10 and COVID-19.