Similarly, in osteoblasts of two murine OI models carrying G349C mutation in COL1A1 (Brtl mouse) and G610C in COL1A2 (Amish mouse), 4-PBA prevented collagen type I accumulation through increased its secretion and reduction of aggregates in mutant cells [16]. The gene discussed is COL1A2; the disease is osteogenesis imperfecta.