Through HE staining experiments, it was observed that some cell necrosis and even liquefaction occurred in the tumours formed by Keap1+/+ and Keap1β(Keap1Δ1–31) cell lines, among which Keap1+/+ cells had more necrosis, whereas there was almost no similar pathology in tumours formed by Keap1−/− cells (Figure S9A). This evidence concerns the gene KEAP1 and neoplasm.