KEAP1 and neoplasm: Further immunohistochemical examinations revealed significant enhancements of Keap1 in the Keap1-Restored and Keap1α-Restored derived xenograft tissues (Figure S11B), and the expression of PTEN was markedly decreased in the Keap1-Restored cell-derived tumour tissue, but also strikingly increased in the Keap1α-Restored cell-derived tumour tissue (Figure S11C).