AKT1 and neoplasm: The results obtained from Keap1−/− and Keap1β(Keap1Δ1–31) cells unraveled that PTEN was obviously upregulated, whilst PI3K, AKT1, and mTOR were all downregulated (Figure 3I,J), showing the similar trends to those of in vivo growing tumours (Figure 3A–C).