IL-8 and TGFβ have been reported as capable of modulating the permanence of leukemic cells [23,24]; PIGF promotes BM angiogenesis [9], and MCP1 has been shown to block the cell cycle of normal but not CML progenitor cells [25]. This evidence concerns the gene CXCL8 and chronic myelogenous leukemia, BCR-ABL1 positive.