Schlaepfer David D et al. synthesized a series of PROTACs [38] based on CRBN ligand and FAK inhibitor PND-1186 through a series of CRBN and PEG connections, among which compound PROTAC 4 (Table 1) observed significant degradation of FAK in human pancreatic cancer cell PA-TU-8988 T cells and PA-TU-8988 T xenograft model in nude mice. The gene discussed is PTK2; the disease is pancreatic neoplasm.