In addition, we analyzed published single-cell sequencing datasets for pancreatic cancer (GSE148073 and GSE154778) and the final results show that the expression level of the PHLDA family is high in tumor tissues such as the TFF1 ductal cell and MET epithelial cell, but very low in immune infiltrating cells (Supplementary Figure S5). Here, TFF1 is linked to pancreatic neoplasm.