IGKV1D-22 and metastatic melanoma: For example, TLR4, RAGE, and EMMPRIN were reported to be expressed in metastatic melanoma cells [9,11,12], and the EMMPRIN-mediated stimulation of melanoma cells with the extracellular S100A8/A9 secreted from the lung strongly facilitated the remote metastasis of melanoma cells to the lung [7].