IGKV1D-22 and cancer: In light of a unique trait shared by all secretory S100 proteins—namely, that they induce inflammatory cytokines and chemokines—cancer-induced S100 proteins produced in lung fibroblasts would add an additional source of S100 proteins to augment the main sources of S100A8/A9 secretory production: neutrophils, monocytes, and macrophages.