Previously our lab has verified that both M-MDSC (CD11b+Ly-6G−Ly-6Chi) and PMN-MDSC (CD11b+Ly-6G+Ly-6Clow) recruited in the 4T1 model of breast cancer are T-cell-suppressive, beginning at d 28 post tumor injection [59]. This evidence concerns the gene ITGAM and breast cancer.