Reduced IL-6 from tumor cells also led to increased tumor-infiltrating Th17 and IFN-γ positive Th1/17, supporting the notion that these cells may be transitioning from Th17 to a Th1 phenotype; however, it is important to note that these cells may also give rise to Treg [60,66,67], which were not assessed in the present study. Here, IL6 is linked to neoplasm.