AKT1 and melanoma: At molecular levels, inhibition of ERK (extracellular signal-regulated kinase) and Akt (protein kinase B) pathway was shown to be induced in melanoma A375 cells by euplotin C. In particular, ERK 1/2 and Akt signaling pathways are often aberrantly activated in melanoma, inducing a complex network involved in melanoma cell proliferation and metastasis formation [44,45,46].