Using a combination of longitudinal comparisons and multivariate modeling, we demonstrate that (1) there are inherent fluctuations in CRP, and Th1/Th17 cytokines during a normal pregnancy; (2) serum cytokines are most impacted by IBD, IBD subtypes, delivery, as well as the medications used; (3) specific cytokine changes are correlated with disease activity in women with UC and CD; (4) T1 serum cytokines are correlated with the method of delivery and predict the course of disease in women with UC and CD, respectively. The gene discussed is CRP; the disease is inflammatory bowel disease.