To test the impact of high versus low IL-22 on the clinical course of IBD using this cut-off, we analyzed the remission curves of women with UC separated based on T1 IL-22 (Figure 5C), which showed that women with T1 IL-22 > 0.624 pg/mL were more likely to flare-up during pregnancy (p < 0.0001, N = 12). This evidence concerns the gene IL22 and inflammatory bowel disease.