GPC1 and neoplasm: Considering the functions that the GPC1 protein performs in the context of the tumor cell and tumor microenvironment, the functional neutralization of GPC1 by a specific mAb would provide benefits for reducing tumor growth, metastasis, and angiogenesis, as well as remodeling the tumor microenvironment, making it more susceptible to treatments and reducing the state of immunosuppression [18,19].