Similar to our results where we showed that Hif-1α increases on CMs upon IH, the authors also demonstrate that Hif-1α is upregulated in monocytes of patients with OSA and that ex vivo inhibition of Hif-1α led to a reduction in inflammasome transcription, suggesting that Hif-1α may play a prominent role in the priming step. This evidence concerns the gene HIF1A and obstructive sleep apnea syndrome.