Then, the altered miRNAs in the aorta from ApoE−/− mice fed with the corresponding diets for 18 weeks were studied in human aortic and carotid samples, using vascular samples from control subjects (CAs), subjects with fibrolipidic plaques (FAs) or patients with advanced carotid atherosclerosis (ACA). Here, APOE is linked to carotid atherosclerosis.