In this regard, the overexpression of miR-155-5p observed in advanced atherosclerosis could be induced by NF-κB activation itself since some groups have described a significant NF-κB activation in carotid advanced atherosclerosis [39,40] as well as in aortic root from ApoE−/− mice under HFD [41], both similar to the samples used by us. This evidence concerns the gene APOE and atherosclerosis.