Comi et al., evaluated long-term lymphocyte count changes in pooled data from the 2-year CLARITY study followed by 2-year CLARITY Extension studies and the PREMIERE registry, finding that the median CD4+ T cell counts recovered ~43 weeks after CLD treatment in year 2, but median CD8+ cell counts remained below their threshold value [12]. Here, CD8A is linked to congenital secretory chloride diarrhea 1.