Using HDR, a single-strand DNA sequence encoding a myc epitope tag (EQKLISEEDL) was introduced into the gene of TDP-43 zebrafish ortholog, which, in humans, is involved in the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) [71]. Here, TARDBP is linked to frontotemporal dementia.