Hence, to investigate the potential correlation between stem cell-derived genetic signatures and KDM5C expression, we measured—in our cohort of GBM patients—the expression levels of four GBM stemness markers: the transcription factor genes NANOG homeobox (NANOG), organic cation/carnitine transporter 4 (OCT4), and sex-determining region Y box 2 (SOX2) and the neuroectodermal marker NESTIN [52]. This evidence concerns the gene SOX2 and glioblastoma.