KDM5C and glioblastoma: Finally, since KDM5C specifically regulates several hypoxia-related genes and targets hypoxia-mediated mechanisms are considered an attractive approach to improve the therapy outcome in GBM [34], the discovery of new hypoxia-related signatures could accelerate the identification of more effective mechanism-based therapies and the development of predictive biomarkers, potentially linked to tumor-related epilepsy.