Next, given the enrichment of genes differentially methylated belonging to the Reactome pathway “inflammation”, we measured the gene expression of Triggering Receptor Expressed on Myeloid cells-2 (TREM2), a microglia surface receptor involved in neuroinflammation that is overexpressed in the glioma and associated with tumor progression [54,55]. This evidence concerns the gene TREM2 and central nervous system cancer.