TP53 and gastric cancer: Since p53 expression has been postulated to be modulated by KDM5C (e.g., gastric cancer cell lines and gastric tumors) [10] and “p53 signaling” ranked among the top Reactome pathways enriched for differentially methylated genes between the KDM5CHigh and KDM5CLow subgroups (TCGA), we quantified p53 by immunohistochemistry in the biopsies of the entire cohort of tumor samples.