Related to these previous findings, our data corroborate the strong interplay between p75NTR and Hif-1α and between Hif-1α and Survivin in GBM and, above all, suggest that the p75NTR–HIF1A–KDM5C–survivin axis could be a new oncogenic hypoxia-mediated gene target with high therapeutic potential. This evidence concerns the gene KDM5C and glioblastoma.