NOP2 and cancer: Among these genes, 90% (46/51) are implicated in cancer (Table S2), including seven involved in glioblastoma pathogenesis, such as Polypyrimidine tract binding protein 2 (PTBP2), encoding a splicing factor aberrantly overexpressed in GBM [45] and NOP2/Sun RNA methyltransferase 6 (NSUN6) encoding the RNA 5-methyl cytosine (5mC) transferase that regulates the glioblastoma response to temozolomide [46].