BDNF and neoplasm: As shown in Figure 2A, KDM5C-overexpressing cells display a significant downregulation of BDNF; while no effects were observed for HIF1A (Figure 2A), NGF, and p75NTR (Figure S1F), suggesting that one of the primary events of KDM5C induction in tumor cells could be the transcriptional repression of the BDNF gene.