Since IL6 overexpression is induced by hypoxia [65], and as IL6 may strongly induce NANOG expression and promote proliferation and stemness in other tumors [66,67,68], the co-expression of IL6-NANOG likely represents a hypoxia-induced module, which appears as a distinctive feature of the KDM5CHigh GBM phenotype. The gene discussed is NANOG; the disease is glioblastoma.