Many of the 12 additional proteins that were linked to incident SCD in the crude model (KIM1, OPG, FGF23, OSM, CDCP1, PDGFC, IL18, VEGFA, CALCA, IL6, TNFSF14, and IL18R1) are well described within the context of CVD. This evidence concerns the gene TNFRSF11B and Schnyder corneal dystrophy.