Many of the 12 additional proteins that were linked to incident SCD in the crude model (KIM1, OPG, FGF23, OSM, CDCP1, PDGFC, IL18, VEGFA, CALCA, IL6, TNFSF14, and IL18R1) are well described within the context of CVD. The gene discussed is IL18R1; the disease is Schnyder corneal dystrophy.