FoxO1 (p = 1.19 × 10−4, 5.16 × 10−7), FoxO3 (p = 2.94 × 10−5, 3.07 × 10−7) and FoxO4 (p = 2.39 × 10−8, 1.0 × 10−6) were predicted to be upstream regulators in liver and lung metastasis, whereas only FoxO1 (p = 2.6 × 10−3) and FoxO4 (p = 4.59 × 10−2) were predicted as upstream regulators in primary breast tumors. Here, FOXO3 is linked to breast neoplasm.