Analysis of the mRNA expression of the FoxO family and SIRT1 in TCGA (The Cancer Genome Atlas) revealed that all genes were downregulation in tumors compared to normal tissues in TNBC (triple-negative breast cancer) (p < 0.05 for FoxO1, FoxO4) (Figure 6a,b). The gene discussed is FOXO4; the disease is triple-negative breast carcinoma.