F8 and hemophilia A: In an ongoing phase 1⁄2 study (NCT02576795), an infusion of valoctocogene roxaparvovec was administered to 15 adults with severe hemophilia A (FVIII ≤ 1 IU/dL) at doses of 6 × 1012 viral genome (vg)/kg (n = 1), 2 × 1013 vg/kg (n = 1), 6 × 1013 vg/kg (n = 7) or 4 × 1013 vg/kg (n = 6) [64,65,69].