The univariate analysis results for PTGER4 methylation indicated that patients diagnosed with Stage III + IV CRC exhibited unfavorable RFS [HR (95% CI) = 6.32 (3.11–12.86)], which remained significant even after confounding variables were included in the multivariable analysis for normal tissue and tumor tissue [HR (95% CI) = 6.67 (2.31–19.28) for normal tissue; 6.70 (2.31–19.41) for tumor tissue]. Here, PTGER4 is linked to neoplasm.