Furthermore, TQ doses of 10, 20, and 40 mg/kg/day administered in AD model rats significantly reduced the expression of TLR2, TLR4, myeloid differential factor 88, tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), interferon-β, interferon regulatory factor 3 (IRF-3), and nuclear factor-κB (NF-κB) [49], as similar seen in LPS/IFN-γ-activated BV-2 microglia cells [48]. Here, IRF3 is linked to Alzheimer disease.