VEGFA and cancer: Many studies have reported that the anticancer effects of resveratrol are effective on all cancer development stages (initiation, promotion, and progression) and can intervene in several signaling pathways such as the activation of pro-apoptosis pathways (p53, Bax/Bcl-2), the resistance of cell cycle (Cyclin, P21), the inhibition of metastasis and angiogenesis related pathways (VEGF, TGF-, MMP), and the regulation of inflammatory responses (NFB, MAPK).