Resveratrol was studied in vitro on AK4-knockdown colon cancer cells (SW480 and SW620) and showed that it could diminish the invasion and metastasis of colon cancer cells by reversing the expression of EMT (epithelial–mesenchymal transition) markers via the AKT/GSK-3β/Snail pathway. The gene discussed is AK4; the disease is malignant colon neoplasm.