Some of enrichment pathways were immune-related, including “Inflammatory Response”, “IL6-JAK-STAT Signaling”, “Interferon-Gamma-Response” and “IL2-STAT5 Signaling” (Figure 4C), which suggested that the effect of different DDRs on the prognosis of PAAD may be related to the activation of the immune pathway. Here, IL6 is linked to pancreatic adenocarcinoma.