Compared to the solely vaccinated mice with pTRP2 (tyrosinase-related protein-2, a highly expressed glycoprotein in human melanomas), the higher percentage of TRP2-specific IFN-γ-producing CD8+ T cells and more durable stronger resistance to B16 melanoma was detected in co-vaccinated mice with pZBP1 and pTRP2 [187]. The gene discussed is CD8A; the disease is melanoma.