Co-inoculation of the plasmid expressing ZBP1 (pZBP1) and the DNA vaccine encoding immunogenic tumor-associated antigens (TAAs) in mice more effectively activated NF-κB and IFN-I signaling and enhanced the TAA-specific cytotoxic CD8+ T lymphocytes (CTLs) and CD4+ Th1 responses, compared to the empty vector plus TAAs vaccine inoculation [187]. The gene discussed is ZBP1; the disease is neoplasm.