TGFB1 and open-angle glaucoma: The LC site is considered a significant location of optic nerve fibre damage in glaucoma as LC cells are similar to myofibroblasts, which are known to be responsible for fibrotic disease development elsewhere in the human body [23] Profibrotic changes elicited by TGF-β within the ONH have been implicated in POAG and pseudoexfoliation glaucoma (PXFG) and include altered turnover of ECM components, formation of cross-linked actin networks (CLANS), upregulation of alpha smooth muscle actin (αSMA), and actin stress fibre formation [4,11,12,13,19,20,21,22,23,24].