The Kelch-like ECH-associated protein 1 (Keap1)-Nrf2-ARE pathway is principal in the adjustment of oxidative stress and homeostasis of the reverse inflammatory reaction by not only regulating antioxidant genes, which mediate transcription process for conservation of cytoplasmic constancy, but detoxification genes for operating and degrading cancer-causing agents and toxic elements before injury [4]. The gene discussed is KEAP1; the disease is cancer.