Significantly higher Gal-3/TNF-α (p = 0.001), Gal-3/IL-6 (p = 0.004), and Gal-3/IL-12 (p = 0.001) and lower Gal-3/IL-17 (p = 0.001) were detected in gonarthrosis patients with DM compared to gonarthrosis patients without DM. This evidence concerns the gene TNF and diabetes mellitus.