IL-10/TNF-α (p = 0.001), IL-10/IL-6 (p = 0.001), and IL-10/IL-12 (p = 0.001) were significantly higher, while IL-10/IL-17 (p = 0.001) ratio was significantly lower in gonarthrosis patients with DM compared to gonarthrosis patients without DM. The gene discussed is IL17A; the disease is osteoarthritis, knee.