As our study showed a lower level of Gal-3 as well as TNF-α, IL-6, IL-12, IFN-γ, and IL-17 in gonarthrosis patients with DM, we believe that the lack of these cytokines caused intense tissue damage and slower tissue repair, which is reflected through a higher WOMAC score (Table 2). This evidence concerns the gene LGALS3 and osteoarthritis, knee.