Significantly lower concentration of TNF-α (p = 0.001), IL-6 (p = 0.001), IL-12 (p = 0.001), IL-17 (p = 0.001), IFN-γ (p = 0.014), and Gal-3 (p = 0.040) was found in gonarthrosis patients with DM compared to gonarthrosis patients without DM. This evidence concerns the gene LGALS3 and diabetes mellitus.