The meta-analysis of four studies [16,28,29,30] by the random-effects model showed that patients with severe malaria had an equal mean of PCT compared to those with uncomplicated malaria (p: 0.055, WMD: 6.93, 95% CI: −0.16–14.02, I2: 84.6%, four studies, Figure 3). This evidence concerns the gene CALCA and malaria.