RAD51 and cannabis dependence: As shown in Table 13 there were nine hits for RAD51 which occurred in both cannabis dependence and withdrawal (Bonferroni-adjusted p-values from 0.0009 to 0.0262) and only one for RAD52 indicating that cannabis blocks RAD51 and homologous recombination much more severely than lower fidelity pathways such as microhomology-mediated repair which forces errors into centrosomal replication and downstream chromosomal mis-segregation events [141].